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Allele Symbol Allele Name Allele ID |
Smarca4tm1.1Pcn targeted mutation 1.1, Pierre Chambon MGI:5009421 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 2 of 19 mice
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• in 2 of 19 mice
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• in 2 of 19 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are present at P10
• no mice survives beyond 2 weeks
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• by 7 to 10 days, all mice develop enlarged gastrointestinal tract unlike control mice
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• mice exhibit dilated intestines filled with air and fecal matter unlike control mice
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• at E17.5, mice exhibit shorter small intestine compared with control mice
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• at E17.5, mice exhibit shorter small intestine compared with control mice
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• at E17.5, mice exhibit shorter small intestine compared with control mice
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• in neonates, smooth muscle cell apoptosis in the proximal and distal colon is increased compared to in control mice
• however, proliferation of intestinal smooth muscle cell is equivalent to in wild-type mice
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• cannulated colonic segments fail to exhibit spontaneous contractile activity compared with control tissue
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• by 7 to 10 days, all mice exhibit enlarged urinary bladder unlike control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by 4 weeks of age
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• the colon is shorter than in wild-type mice
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• enlarged by 4 weeks of age
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• mice exhibit short smaller intestine
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are present at P10 due to cardiopulmonary defects
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• smooth muscle cells are disorganized in the colon compared to in wild-type mice
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• in neonates, the colon is shorter than in wild-type mice
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• mice exhibit enlarged ileum and jejunum compared with wild-type mice
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• mice exhibit enlarged ileum compared with wild-type mice
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• mice exhibit enlarged jejunum compared with wild-type mice
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• in neonates, the small intestines are shorter than in wild-type mice
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• smooth muscle cells are disorganized in the colon compared to in wild-type mice
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• in neonates, smooth muscle cell apoptosis in the proximal and distal colon is increased compared to in wild-type mice
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• in response to KCl or carbachol, colonic rings exhibit impaired contractility compared with wild-type tissue
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• in cyanotic mice
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• in cyanotic mice
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• in 6 of 18 mice at P0 to P2
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• lungs are hyperemic with accumulation of eosinophilic lipoproteinaceous material in the alveolar air space compared to in wild-type mice
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• lungs are hyperemic with accumulation of eosinophilic lipoproteinaceous material in the alveolar air space compared to in wild-type mice
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• in cyanotic mice
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• in cyanotic mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal intestines and colonic ring contractility
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• however, colonic ring contractility is normal
• in neonates, intestinal smooth muscle cell proliferation is increased compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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