All Phenotypes Smad1<tm1.1Abr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smad1^tm1.1Abr
targeted mutation 1.1, Anita B Roberts
MGI:5009225

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Smad1^tm1Abr/Smad1^tm1.1Abr Tg(Col2a1-cre)1Bhr/0	involves: BALB/cJ * C57 * C57BL/6 * SJL	MGI:5009239
cn2	Smad1^tm1Abr/Smad1^tm1.1Abr Tg(Col1a1-cre)1Kry/0	involves: BALB/cJ * C57 * FVB	MGI:5009240

Allelic Composition	Smad1^tm1Abr/Smad1^tm1.1Abr Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: BALB/cJ * C57 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1^tm1.1Abr mutation (0 available); any Smad1 mutation (32 available)
Smad1^tm1Abr mutation (1 available); any Smad1 mutation (32 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal neurocranium morphology ( J:172689 )

• at E16.5, calvarial bone formation and mineralization is reduced compared to in wild-type mice

delayed bone ossification ( J:172689 )

• at E16.5, mice exhibit delayed ossification of the frontal, parietal, and supraoccipital bones compared with wild-type mice

• at E16.5, formation of ossification centers in the proximal phalangeal bones is delayed compared to in wild-type mice

• at E16.5, calvarial bone formation and mineralization is reduced compared to in wild-type mice

• however, embryos appeared normal by E18.5

craniofacial

abnormal neurocranium morphology ( J:172689 )

• at E16.5, calvarial bone formation and mineralization is reduced compared to in wild-type mice

Allelic Composition	Smad1^tm1Abr/Smad1^tm1.1Abr Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: BALB/cJ * C57 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased osteoblast proliferation ( J:172689 )

• osteoblast proliferation is reduced compared to in wild-type mice

decreased osteoblast cell number ( J:172689 )

abnormal trabecular bone morphology ( J:172689 )

• mice exhibit increased trabecular separation and structural model index compared with wild-type mice

decreased trabecular bone volume ( J:172689 )

• at 2 months

decreased bone trabecula number ( J:172689 )

increased bone trabecular spacing ( J:172689 )

decreased trabecular bone connectivity density ( J:172689 )

decreased trabecular bone thickness ( J:172689 )

abnormal skeleton development ( J:172689 )

• bone formation rate is reduced compared to in wild-type mice

impaired osteoblast differentiation ( J:172689 )

• osteoblast differentiation is impaired compared to in wild-type mice

cellular

impaired osteoblast differentiation ( J:172689 )

• osteoblast differentiation is impaired compared to in wild-type mice

decreased osteoblast proliferation ( J:172689 )

• osteoblast proliferation is reduced compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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