Phenotypes associated with this allele

• Allele Symbol: Adamts4^tm1.1Boer
• Allele Name: targeted mutation 1.1, Derek Boerboom
• Allele ID: MGI:5009124
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts4^tm1.1Boer/Adamts4^tm1.1Boer	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:5009126
cx2	Adamts1^tm1Mapr/Adamts1^tm1Mapr Adamts4^tm1.1Boer/Adamts4^tm1.1Boer	involves: 129 * BALB/cJ * C57BL/6J	MGI:5009127

Genotype
MGI:5009126

hm1

• Allelic Composition: Adamts4^tm1.1Boer/Adamts4^tm1.1Boer
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:172645 )

• viable and fertile with no gross abnormalities

Genotype
MGI:5009127

cx2

• Allelic Composition: Adamts1^tm1Mapr/Adamts1^tm1Mapr; Adamts4^tm1.1Boer/Adamts4^tm1.1Boer
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6J

mortality/aging

postnatal lethality, incomplete penetrance ( J:172645 )

• more than 95% of mice die within 72 hours of birth

• mice that survive past 72 hours live to adulthood

renal/urinary system

renal/urinary system phenotype ( J:172645 )

N • morphology of the renal cortex is essentially normal

kidney medulla atrophy ( J:172645 )

• irregularly and markedly thinned in newborns and the few surviving adults

hydronephrosis ( J:172645 )

• the renal pelvis is dilated in newborns and the few surviving adults

• no signs of urinary tract obstruction are detected