About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PDGFB-UCHL1*I93M)LWada
transgene insertion L, Keiji Wada
MGI:5008736
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(PDGFB-UCHL1*I93M)LWada/0 involves: C57BL/6J MGI:5008739


Genotype
MGI:5008739
tg1
Allelic
Composition		 Tg(PDGFB-UCHL1*I93M)LWada/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:128045 )
N
• in the absence of MPTP treatment no loss of dopaminergic neurons is detected unlike in mice carrying Tg(PDGFB-UCHL1*I93M)HWada
increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )
• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls

homeostasis/metabolism
increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )
• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls

cellular
increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )
• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory