Phenotypes associated with this allele

• Allele Symbol: Tg(PDGFB-UCHL1*I93M)LWada
• Allele Name: transgene insertion L, Keiji Wada
• Allele ID: MGI:5008736
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(PDGFB-UCHL1*I93M)LWada/0	involves: C57BL/6J	MGI:5008739

Genotype
MGI:5008739

tg1

• Allelic Composition: Tg(PDGFB-UCHL1*I93M)LWada/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:128045 )

N • in the absence of MPTP treatment no loss of dopaminergic neurons is detected unlike in mice carrying Tg(PDGFB-UCHL1*I93M)HWada

increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )

• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )

• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )

• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls