All Phenotypes Akr1b1<tm1.1Kgab> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akr1b1^tm1.1Kgab
targeted mutation 1.1, Kenneth H Gabbay
MGI:5008171

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab	B6.Cg-Akr1b1^tm1.1Kgab	MGI:5008184
cx2	Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab	B6.Cg-Akr1a1^{Gt(OST222400)Lex} Akr1b1^tm1.1Kgab	MGI:5008183

Allelic Composition	Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab
Genetic Background	B6.Cg-Akr1b1^tm1.1Kgab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1b1^tm1.1Kgab mutation (0 available); any Akr1b1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal vitamin C level ( J:164548 )

• male mice exhibit a decrease in liver and kidney ascorbate levels compared with wild-type mice

Allelic Composition	Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab
Genetic Background	B6.Cg-Akr1a1^{Gt(OST222400)Lex} Akr1b1^tm1.1Kgab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1a1^{Gt(OST222400)Lex} mutation (0 available); any Akr1a1 mutation (30 available)
Akr1b1^tm1.1Kgab mutation (0 available); any Akr1b1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

"Rachitic rosary" phenotype of Gulo^tm1Mae/Gulo^tm1Mae and Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} bones

mortality/aging

premature death ( J:164548 )

• mice die at 8 to 10 weeks of age

skeleton

rachitic rosary ( J:164548 )

• newborn mice exhibit rapid onset of scurvy with ball-like swellings at the costochondral junction of the ribs resulting from hemorrhage and callus formation due to profound ascorbate deficiency

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