Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-TLE3)#aPton
• Allele Name: transgene insertion #a, Peter Tontonoz
• Allele ID: MGI:5007704
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Fabp4-TLE3)#aPton/0	involves: C57BL/6	MGI:5007716

Genotype
MGI:5007716

tg1

• Allelic Composition: Tg(Fabp4-TLE3)#aPton/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired adaptive thermogenesis ( J:198134 )

• impaired ability to respond to cold exposure

increased circulating resistin level ( J:172245 )

• when fed a high-fat diet, mice exhibit increased plasma levels of resistin compared with wild-type mice

• however, leptin levels are normal

decreased energy expenditure ( J:172245 , J:198134 )

• modest when fed a high-fat diet (J:172245)

• when housed in metabolic cages (J:198134)

abnormal glucose homeostasis ( J:172245 )

• mice fed a high-fat diet exhibit improved glucose homeostasis compared with wild-type mice

• however, mice fed a standard chow diet exhibit normal glucose homeostasis

decreased circulating glucose level ( J:172245 )

• in fasting mice when fed a high-fat diet

decreased circulating insulin level ( J:172245 )

• when fed a high-fat diet

improved glucose tolerance ( J:172245 )

• when fed a high-fat diet

increased insulin sensitivity ( J:172245 )

• when fed a high-fat diet

increased circulating adiponectin level ( J:172245 )

• when fed a high-fat diet, mice exhibit increased plasma levels of adiponectin compared with wild-type mice

adipose tissue

abnormal brown fat cell morphology ( J:198134 )

• brown adipose tissue exhibits an increase in the number of cells with large unilocular lipid droplets similar to white adipose tissue unlike in wild-type mice

increased epididymal fat pad weight ( J:172245 )

• when fed a high-fat diet

liver/biliary system

decreased liver weight ( J:172245 )

• when fed a high-fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:172245 )

• when fed a high-fat diet

behavior/neurological

decreased food intake ( J:172245 , J:198134 )

• when fed a high-fat diet (J:172245)

• when housed in metabolic cages (J:198134)

hyperactivity ( J:198134 )

• when housed in metabolic cages