Phenotypes associated with this allele

• Allele Symbol: Tph2^tm1.1Zfc
• Allele Name: targeted mutation 1.1, Zhou-Feng Chen
• Allele ID: MGI:5007662
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph2^tm1.1Zfc/Tph2^tm1.1Zfc	involves: 129S7/SvEvBrd	MGI:5007702

Genotype
MGI:5007702

hm1

• Allelic Composition: Tph2^tm1.1Zfc/Tph2^tm1.1Zfc
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal mating preference ( J:170988 )

• male mice exhibit increased male-male mounting compared with control mice

• male mice fail to exhibit an increase in mounting estrous female unlike wild-type mice

• male mice fail to exhibit a preference for female bedding unlike control mice

• male mice fail to exhibit a preference for female genital odor unlike control mice

• however, treatment with 5-hydroxytryptophan rescues male preference for female bedding

homeostasis/metabolism

decreased serotonin level ( J:170988 )

• in the brain of male mice