Phenotypes associated with this allele

• Allele Symbol: Tlr3^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007360
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr3^tm1Lex/Tlr3^tm1Lex	B6;129S5-Tlr3^tm1Lex/Tac	MGI:8375538

Genotype
MGI:8375538

hm1

• Allelic Composition: Tlr3^tm1Lex/Tlr3^tm1Lex
• Genetic Background: B6;129S5-Tlr3^tm1Lex/Tac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

delayed wound healing ( J:169762 )

• wound healing of full thickness circular skin opennings are markedly delayed

• full wound closure around 14 days rather than 12 days as in controls

• reduced infiltration of neutrophiles at days 1 and 3 and of macrophage at days 3 and 6

• reduced presence of chemokines involved in leukocyte recruitment