About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mpzl2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007250
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mpzl2tm1Lex/Mpzl2tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:5429590


Genotype
MGI:5429590
hm1
Allelic
Composition		 Mpzl2tm1Lex/Mpzl2tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpzl2tm1Lex mutation (3 available); any Mpzl2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:171883 )
• decreased mean percentage of B cells in the peripheral blood
• slightly decreased percentage of CD21Hi/CD23med cells in spleen
increased CD8-positive, alpha-beta T cell number ( J:171883 )
• increased mean percentage of CD8 cells in peripheral blood

immune system
decreased B cell number ( J:171883 )
• decreased mean percentage of B cells in the peripheral blood
• slightly decreased percentage of CD21Hi/CD23med cells in spleen
increased CD8-positive, alpha-beta T cell number ( J:171883 )
• increased mean percentage of CD8 cells in peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory