Phenotypes associated with this allele

• Allele Symbol: Il17re^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007190
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il17re^tm1Lex/Il17re^tm1Lex	B6.129S5-Il17re^tm1Lex	MGI:5304814

Genotype
MGI:5304814

hm1

• Allelic Composition: Il17re^tm1Lex/Il17re^tm1Lex
• Genetic Background: B6.129S5-Il17re^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:178967 )

• DSS-treated mice exhibit increased goblet cell loss compared with wild-type mice

abnormal large intestine crypts of Lieberkuhn morphology ( J:178967 )

• DSS-treated mice exhibit increased crypt loss despite crypt epithelium hyperplasia compared with wild-type mice

increased susceptibility to induced colitis ( J:178967 )

• DSS-treated mice exhibit increased weight loss, inadequate resolution of inflammation, expansion of lamina propria and crypt epithelial cell hyperplasia, loss of goblet cells, colon inflammation, crypt loss, and proinflammatory cytokines and chemokines compared with wild-type mice

integument

psoriasis ( J:178967 )

• in imiquimod-treated mice as measured by ear thickness

abnormal keratinocyte physiology ( J:178967 )

• keratinocytes lose their responsiveness to IL17C

• however, IL17A responsiveness is intact

growth/size/body

increased susceptibility to weight loss ( J:178967 )

• in DSS-treated mice

immune system

increased susceptibility to induced colitis ( J:178967 )

• DSS-treated mice exhibit increased weight loss, inadequate resolution of inflammation, expansion of lamina propria and crypt epithelial cell hyperplasia, loss of goblet cells, colon inflammation, crypt loss, and proinflammatory cytokines and chemokines compared with wild-type mice

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:178967 )

• DSS-treated mice exhibit increased crypt loss despite crypt epithelium hyperplasia compared with wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:178967 )

• DSS-treated mice exhibit increased goblet cell loss compared with wild-type mice