All Phenotypes Hsd17b13<tm1Lex> MGI Mouse

reproductive system

reproductive system phenotype ( J:273927 )

N	• mice exhibit normal fertility

liver/biliary system

• in male mice at 9 months of age

liver inflammation ( J:273927 )

• portal inflammation and ductular proliferation in male mice by 3 months of age with microgranulomas

hepatic steatosis ( J:273927 )

• in male mice from 3 months of age with micro- and macrovesicular steatosis in most mice by 9 months of age

macrovesicular hepatic steatosis ( J:273927 )

• in most male mice by 9 months of age

microvesicular hepatic steatosis ( J:273927 )

• in most male mice by 9 months of age

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:273927 )

N	• male mice exhibit normal glucose tolerance and hepatic glucose output

• in hepatic mitochondria of male mice

• in male mice at 9 months of age

increased lipogenesis ( J:273927 )

• increased hepatic de novo lipogenesis and fatty acid esterification as determined by gene expression analysis in male mice

immune system

liver inflammation ( J:273927 )

• portal inflammation and ductular proliferation in male mice by 3 months of age with microgranulomas

cellular

• in hepatic mitochondria of male mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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