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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glt8d2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007158
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glt8d2tm1Lex/Glt8d2tm1Lex B6;129S5-Glt8d2tm1Lex/Mmucd MGI:5882202


Genotype
MGI:5882202
hm1
Allelic
Composition		 Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic
Background		 B6;129S5-Glt8d2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glt8d2tm1Lex mutation (2 available); any Glt8d2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:171883 )
• slightly reduced viability is observed

immune system
decreased IgG1 level ( J:171883 )
• decreased mean serum IgG1 and IgG2a responses to ovalbumin challenge
decreased IgG2a level ( J:171883 )
• decreased mean serum IgG1 and IgG2a responses to ovalbumin challenge

hematopoietic system
decreased IgG1 level ( J:171883 )
• decreased mean serum IgG1 and IgG2a responses to ovalbumin challenge
decreased IgG2a level ( J:171883 )
• decreased mean serum IgG1 and IgG2a responses to ovalbumin challenge




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory