About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glb1l2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007155
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glb1l2tm1Lex/Glb1l2tm1Lex B6;129S5-Glb1l2tm1Lex/Mmucd MGI:5829230


Genotype
MGI:5829230
hm1
Allelic
Composition		 Glb1l2tm1Lex/Glb1l2tm1Lex
Genetic
Background		 B6;129S5-Glb1l2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glb1l2tm1Lex mutation (2 available); any Glb1l2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased leukocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean white blood cell counts when compared with controls
decreased lymphocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased lymphocyte counts when compared with controls
decreased NK cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean percentage of natural killer cells when compared with controls

homeostasis/metabolism
impaired glucose tolerance ( J:171883 )
• male mutant mice exhibit impaired glucose tolerance when compared with controls

immune system
decreased leukocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean white blood cell counts when compared with controls
decreased lymphocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased lymphocyte counts when compared with controls
decreased NK cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean percentage of natural killer cells when compared with controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory