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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gfraltm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007153
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gfraltm1Lex/Gfraltm1Lex B6.129S5-Gfraltm1Lex MGI:6140072


Genotype
MGI:6140072
hm1
Allelic
Composition
Gfraltm1Lex/Gfraltm1Lex
Genetic
Background
B6.129S5-Gfraltm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfraltm1Lex mutation (2 available); any Gfral mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• no reduction in food intake when fed regular chow and administered Gdf15, whereas in wild-type mice intake reduces
• no reduction in food intake when fed regular chow and administered chemotherapeutic agent cisplatin, whereas in wild-type mice intake reduces
• when fed high-fat diet

growth/size/body
• no reduction in body weight when fed regular chow and administered Gdf15, whereas in wild-type mice weight reduces
• no reduction in body weight, adipose tissue, and fat and lean mass when fed regular chow and administered chemotherapeutic agent cisplatin, whereas in wild-type mice they reduce
• reduction in body weight when fed regular chow and administered Gcg (glucagon)
• gained more weight than wild-type mice when fed high-fat diet for 12 weeks: 32% greater total fat mass and 9% greater lean mass
• no weight gain differences with wild-type mice when fed regular chow

homeostasis/metabolism
N
• energy expenditure when fed regular chow
• gained more weight than wild-type mice when fed high-fat diet for 12 weeks: 32% greater total fat mass and 9% greater lean mass
• no weight gain differences with wild-type mice when fed regular chow
• no changes after 6 hours of fasting when fed high-fat diet, whereas in wild-type mice it does change
• when fed high-fat diet
• no changes after 6 hours of fasting when fed high-fat diet, whereas in wild-type mice it does change





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory