Phenotypes associated with this allele

• Allele Symbol: Cpxm2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007085
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpxm2^tm1Lex/Cpxm2^tm1Lex	B6;129S5-Cpxm2^tm1Lex/Mmucd	MGI:7595839

Genotype
MGI:7595839

hm1

• Allelic Composition: Cpxm2^tm1Lex/Cpxm2^tm1Lex
• Genetic Background: B6;129S5-Cpxm2^tm1Lex/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:345349 )

N • in the absence of deoxycorticosterone acetate treatment heart morphology and blood pressure are similar to wild-type mice

abnormal heart left ventricle morphology ( J:345349 )

• unlike in wild-type mice deoxycorticosterone acetate does not induce an increase in left ventricular perivascular fibrosis

• interstitial fibrosis induced by deoxycorticosterone acetate is reduced compared to wild-type mice

abnormal heart left ventricle weight ( J:345349 )

• increase in left ventricular weight induced by deoxycorticosterone acetate treatment is significantly less than in similarly treated wild-type mice

decreased heart rate ( J:345349 )

• heart rate is slightly but significantly lower at baseline compared to wild-type controls

• however, increase in heart rate in response to deoxycorticosterone acetate treatment is similar to wild-type mice

decreased response of heart to induced stress ( J:345349 )

• attenuation of reduction in left ventricular ejection fraction and progressive enlargement of end-systolic and end-diastolic left ventricular internal diameters in response to deoxycorticosterone acetate treatment compared to wild-type mice

homeostasis/metabolism

decreased response of heart to induced stress ( J:345349 )

• attenuation of reduction in left ventricular ejection fraction and progressive enlargement of end-systolic and end-diastolic left ventricular internal diameters in response to deoxycorticosterone acetate treatment compared to wild-type mice

decreased physiological sensitivity to xenobiotic ( J:345349 )

• attenuated cardiac changes in response to deoxycorticosterone acetate treatment although the level of systolic hypertension is similar to wild-type controls

• renal damage induced by deoxycorticosterone acetate treatment is similar to wild-type mice