Phenotypes associated with this allele

• Allele Symbol: Colec11^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007083
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Colec11^tm1Lex/Colec11^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5903276

Genotype
MGI:5903276

hm1

• Allelic Composition: Colec11^tm1Lex/Colec11^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood urea nitrogen level ( J:234934 )

• reduced following 50 minutes of ischemia and 24 hours reperfusion compared with wild-type mice

abnormal complement protein level ( J:234934 )

• reduced deposition of C3d in the kidney following 30 or 50 minutes of ischemia and 24 hours reperfusion compared with wild-type mice

decreased susceptibility to kidney reperfusion injury ( J:234934 )

• following 50 minutes of ischemia and 24 hours reperfusion, mice exhibit reduced tubule necrosis, inflammatory cell infiltration (neutrophils and macrophages), deposition of complement (Cd3d) and blood urea nitrogen levels compared with wild-type mice

• following 30 minutes of ischemia and 24 hours reperfusion, mice exhibit reduced loss of renal function, preservation of renal architecture and reduced leukocyte infiltration and tubular deposition of complement compared with wild-type mice

• transplanted kidneys subjected to ischemia and reperfusion exhibit improved structure and function compared with wild-type kidneys

renal/urinary system

decreased susceptibility to kidney reperfusion injury ( J:234934 )

• following 50 minutes of ischemia and 24 hours reperfusion, mice exhibit reduced tubule necrosis, inflammatory cell infiltration (neutrophils and macrophages), deposition of complement (Cd3d) and blood urea nitrogen levels compared with wild-type mice

• following 30 minutes of ischemia and 24 hours reperfusion, mice exhibit reduced loss of renal function, preservation of renal architecture and reduced leukocyte infiltration and tubular deposition of complement compared with wild-type mice

• transplanted kidneys subjected to ischemia and reperfusion exhibit improved structure and function compared with wild-type kidneys

abnormal renal tubule morphology ( J:234934 )

• reduced tubule necrosis and inflammation following 30 or 50 minutes of ischemia and 24 hours reperfusion compared with wild-type mice

immune system

abnormal complement protein level ( J:234934 )

• reduced deposition of C3d in the kidney following 30 or 50 minutes of ischemia and 24 hours reperfusion compared with wild-type mice