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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ace2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007005
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ace2tm1Lex/Ace2tm1Lex B6;129S5-Ace2tm1Lex/Mmucd MGI:5828264
ot2
Ace2tm1Lex/Y B6;129S5-Ace2tm1Lex/Mmucd MGI:5828265


Genotype
MGI:5828264
hm1
Allelic
Composition
Ace2tm1Lex/Ace2tm1Lex
Genetic
Background
B6;129S5-Ace2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Lex mutation (2 available); any Ace2 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the coats the mutant mice were yellow-tinted when compared with controls

pigmentation
• the coats the mutant mice were yellow-tinted when compared with controls

respiratory system
• mice exposed to cigarette smoke for 3 weeks show a higher level of pulmonary inflammation, with increases in TGF-beta1, TNF-alpha, and IL-6, than exposed wild-type mice
• cigarette smoke exposed mice show an earlier airway epithelial thickening and more severe infiltration of white blood cells around the alveolus compared to exposed wild-type mice
• mice exposed to cigarette smoke for 3 weeks show a greater increase in resting respiratory rate than wild-type mice exposed to smoke

homeostasis/metabolism
• gelatinase activities, including MMP-2 and MMP-9, near the alveolus and bronchioles is continuously and more increased in cigarette exposed mutants than wild-type mice
• pulmonary ACE activity induced by cigarette smoke exposure is greater than in wild-type mice

immune system
• mice exposed to cigarette smoke for 3 weeks show a higher level of pulmonary inflammation, with increases in TGF-beta1, TNF-alpha, and IL-6, than exposed wild-type mice
• cigarette smoke exposed mice show an earlier airway epithelial thickening and more severe infiltration of white blood cells around the alveolus compared to exposed wild-type mice




Genotype
MGI:5828265
ot2
Allelic
Composition
Ace2tm1Lex/Y
Genetic
Background
B6;129S5-Ace2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Lex mutation (2 available); any Ace2 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the coats the mutant mice were yellow-tinted when compared with controls

pigmentation
• the coats the mutant mice were yellow-tinted when compared with controls





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory