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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clmptm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007002
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clmptm1Lex/Clmptm1Lex B6;129S5-Clmptm1Lex/Mmucd MGI:5827982


Genotype
MGI:5827982
hm1
Allelic
Composition		 Clmptm1Lex/Clmptm1Lex
Genetic
Background		 B6;129S5-Clmptm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clmptm1Lex mutation (1 available); any Clmp mutation (200 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:171883 )
• this mutation resulted in reduced viability of the homozygous mutants

growth/size/body
decreased body size ( J:171883 )
• mutants were smaller than controls

cardiovascular system
increased systemic arterial systolic blood pressure ( J:171883 )
• notably increased mean systolic blood pressure

renal/urinary system
hydronephrosis ( J:171883 )
• both CAT-Scan analysis and necropsy revealed bilateral hydronephrosis in surviving homozygous mutant mice

behavior/neurological
abnormal behavior ( J:171883 )
• exhibited numerous neurological abnormalities

homeostasis/metabolism
abnormal blood homeostasis ( J:171883 )
• exhibited numerous blood chemistry abnormalities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory