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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pak2tm1Rjak
targeted mutation 1, Rolf Jakobi
MGI:5006977
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pak2tm1Rjak/Pak2tm1Rjak involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5006979


Genotype
MGI:5006979
hm1
Allelic
Composition		 Pak2tm1Rjak/Pak2tm1Rjak
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pak2tm1Rjak mutation (0 available); any Pak2 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Pak2tm1Rjak/Pak2tm1Rjak embryos are smaller and less developed

mortality/aging
preweaning lethality, complete penetrance ( J:171914 )
• mice start to die at E8.0 with none detected postnatally

embryo
open neural tube ( J:171914 )
• head folds are prominent at E8.0
impaired somite development ( J:171914 )
• very few somites are present at E8.0

growth/size/body
embryonic growth retardation ( J:171914 )
• at E10.5
decreased embryo size ( J:171914 )
• at E10.5

nervous system
open neural tube ( J:171914 )
• head folds are prominent at E8.0




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory