About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79am1Anu
mutation 1, The Australian National University
MGI:5006856
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd79am1Anu/Cd79am1Anu C57BL/6-Cd79am1Anu MGI:5009420
hm2
 		Cd79am1Anu/Cd79am1Anu involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd MGI:5006964
cx3
 		Cd79am1Anu/Cd79am1Anu
Rasgrp1m1Anu/Rasgrp1m1Anu 		involves: C57BL/6JSfdAnu * CBA/J MGI:5565190


Genotype
MGI:5009420
hm1
Allelic
Composition		 Cd79am1Anu/Cd79am1Anu
Genetic
Background		 C57BL/6-Cd79am1Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79am1Anu mutation (2 available); any Cd79a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent pre-B cells ( J:171924 )
• only 15% of mIgM-B220lo cells from bone marrow of mice homozygous for this mutation are positive for cytoplasmic immunoglobulin M heavy chain (c-mu), consistent with the cells' inability to assemble pre-B cell receptors (pre-BCR)

immune system
absent pre-B cells ( J:171924 )
• only 15% of mIgM-B220lo cells from bone marrow of mice homozygous for this mutation are positive for cytoplasmic immunoglobulin M heavy chain (c-mu), consistent with the cells' inability to assemble pre-B cell receptors (pre-BCR)




Genotype
MGI:5006964
hm2
Allelic
Composition		 Cd79am1Anu/Cd79am1Anu
Genetic
Background		 involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79am1Anu mutation (2 available); any Cd79a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent pre-B cells ( J:104190 )
• absolutely no B cells or pre-B cells
decreased IgG level ( J:104190 )
• hypogammaglobulinemia

immune system
absent pre-B cells ( J:104190 )
• absolutely no B cells or pre-B cells
decreased IgG level ( J:104190 )
• hypogammaglobulinemia




Genotype
MGI:5565190
cx3
Allelic
Composition		 Cd79am1Anu/Cd79am1Anu
Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic
Background		 involves: C57BL/6JSfdAnu * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79am1Anu mutation (2 available); any Cd79a mutation (22 available)
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207898 )
N
• profoundly suppressed accumulation of PD1+ Helios+ CD4+ T cells compared with Rasgrp1m1Anu homozygotes
• restored number of effector/memory and regulatory CD4+ T cells compared with Rasgrp1m1Anu homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory