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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe
targeted mutation 8, Scott Lowe
MGI:4999898
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae 		involves: 129S4/SvJae * C57BL/6 MGI:5000007
cx2
 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Tg(CMV-rtTA)4Bjd/0 		involves: 129S4/SvJae * C57BL/6 * NMRI MGI:5000005
cx3
 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Tg(CMV-rtTA)4Bjd/0 		involves: 129S4/SvJae * C57BL/6 * NMRI MGI:5000006


Genotype
MGI:5000007
cx1
Allelic
Composition		 Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe mutation (0 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:171348 )
• most mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body
weight loss ( J:171348 )
• in doxycycline-treated mice

cellular
abnormal cell cycle ( J:171348 )
• doxycycline-treated mice exhibit cell cycle arrest unlike control mice




Genotype
MGI:5000005
cx2
Allelic
Composition		 Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Tg(CMV-rtTA)4Bjd/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe mutation (0 available); any Col1a1 mutation (166 available)
Tg(CMV-rtTA)4Bjd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:171348 )
• most mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body
weight loss ( J:171348 )
• in doxycycline-treated mice

cellular
abnormal cell cycle ( J:171348 )
• doxycycline-treated mice exhibit cell cycle arrest in the liver, spleen, and intestine unlike control mice




Genotype
MGI:5000006
cx3
Allelic
Composition		 Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Tg(CMV-rtTA)4Bjd/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe mutation (0 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(CMV-rtTA)4Bjd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:171348 )
• half of mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body
weight loss ( J:171348 )
• in doxycycline-treated mice

cellular
abnormal cell cycle ( J:171348 )
• doxycycline-treated mice exhibit cell cycle arrest in the liver, spleen, and intestine unlike control mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory