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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flot2Gt(258D8)Cmhd
gene trap 258D8, Centre for Modeling Human Disease
MGI:4968139
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Flot1tm1.1Arte/Flot1tm1.1Arte
Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5697919


Genotype
MGI:5697919
cx1
Allelic
Composition		 Flot1tm1.1Arte/Flot1tm1.1Arte
Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1tm1.1Arte mutation (0 available); any Flot1 mutation (22 available)
Flot2Gt(258D8)Cmhd mutation (0 available); any Flot2 mutation (34 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloid beta deposits ( J:212342 )
• reduced quantity of Abeta fragments

nervous system
amyloid beta deposits ( J:212342 )
• reduced quantity of Abeta fragments




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory