Phenotypes associated with this allele

• Allele Symbol: Polb^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4950969
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polb^tm1a(KOMP)Wtsi/Polb^tm1a(KOMP)Wtsi	C57BL/6N-Polb^tm1a(KOMP)Wtsi/Wtsi	MGI:5700961
ht2	Polb^tm1a(KOMP)Wtsi/Polb^+	C57BL/6N-Polb^tm1a(KOMP)Wtsi/Wtsi	MGI:5782359

Genotype
MGI:5700961

hm1

• Allelic Composition: Polb^{tm1a(KOMP)Wtsi}/Polb^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Polb^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0663_1_B01

Data Sources

IMPC Data for Polb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent trigeminal artery ( J:239583 )

DMDD

retroesophageal left subclavian artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

absent extracranial vertebral artery segment ( J:239583 )

DMDD

inverse situs of great intrathoracic arteries ( J:239583 )

DMDD

absent stapedial artery ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal direction of heart looping ( J:239583 )

DMDD

abnormal interatrial septum morphology ( J:239583 )

DMDD

eye hemorrhage ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal Wolffian duct connection ( J:239583 )

DMDD

abnormal Wolffian duct topology ( J:239583 )

DMDD

endocrine/exocrine glands

adrenal gland hypoplasia ( J:239583 )

DMDD

small thyroid gland ( J:239583 )

DMDD

growth/size/body

dermal cyst ( J:239583 )

DMDD

hearing/vestibular/ear

absent stapedial artery ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

abnormal lymphatic vessel topology ( J:239583 )

DMDD

integument

dermal cyst ( J:239583 )

DMDD

subcutaneous edema ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal eye muscle morphology ( J:239583 )

DMDD

neoplasm

increased trigeminal neuroma incidence ( J:239583 )

DMDD

nervous system

increased trigeminal neuroma incidence ( J:239583 )

DMDD

thin splanchnic nerve ( J:239583 )

DMDD

small superior cervical ganglion ( J:239583 )

DMDD

reduced sympathetic cervical ganglion size ( J:239583 )

DMDD

abnormal brain internal capsule morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

abnormal cerebral cortex morphology ( J:239583 )

DMDD

abnormal hindbrain morphology ( J:239583 )

DMDD

abnormal vagus ganglion morphology ( J:239583 )

DMDD

small superior vagus ganglion ( J:239583 )

DMDD

thin facial nerve ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

thin oculomotor nerve ( J:239583 )

DMDD

thin motoric part of trigeminal nerve ( J:239583 )

DMDD

dorsal root ganglion hyperplasia ( J:239583 )

DMDD

dorsal root ganglion hypoplasia ( J:239583 )

DMDD

skeleton

abnormal cervical rib ( J:239583 )

DMDD

abnormal cervical vertebrae morphology ( J:239583 )

DMDD

abnormal cervical atlas morphology ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

eye hemorrhage ( J:239583 )

DMDD

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD

Genotype
MGI:5782359

ht2

• Allelic Composition: Polb^{tm1a(KOMP)Wtsi}/Polb⁺
• Genetic Background: C57BL/6N-Polb^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0663_1_B01

Data Sources

IMPC Data for Polb

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - WTSI

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

increased mean platelet volume ( J:211773 )

♂

IMPC - WTSI