Phenotypes associated with this allele

• Allele Symbol: Abi1^tm1.2Lko
• Allele Name: targeted mutation 1.2, Leszek Kotula
• Allele ID: MGI:4950558
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abi1^tm1.2Lko/Abi1^tm1.2Lko	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:4950559

Genotype
MGI:4950559

hm1

• Allelic Composition: Abi1^tm1.2Lko/Abi1^tm1.2Lko
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Exencephaly and pericardial edema in Abi1^tm1.2Lko/Abi1^tm1.2Lko embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171342 )

• all die between E10.5 and E11.5

embryo

abnormal pharyngeal arch development ( J:171342 )

• severe abnormalities in the formation of the branchial arches

embryonic growth retardation ( J:171342 )

• marked delay is seen as early as E8.5

open neural tube ( J:171342 )

• seen in some embryos

wavy neural tube ( J:171342 )

• undulation of the neural tube

growth/size/body

embryonic growth retardation ( J:171342 )

• marked delay is seen as early as E8.5

homeostasis/metabolism

pericardial edema ( J:171342 )

• 10 of 20 embryos show pericardial edema at E10.5

cardiac edema ( J:171342 )

nervous system

open neural tube ( J:171342 )

• seen in some embryos

wavy neural tube ( J:171342 )

• undulation of the neural tube

exencephaly ( J:171342 )

• 7 of 20 embryos show exencephaly at E10.5

cardiovascular system

pericardial edema ( J:171342 )

• 10 of 20 embryos show pericardial edema at E10.5

dilated heart ( J:171342 )

• markedly dilated heart at late stages