Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat/Slc18a3tm1.1Vpra mutation
(0 available);
any
Chat mutation
(57 available)
Tg(Chat-COP4*H134R/EYFP,Slc18a3)6Gfng mutation
(1 available)
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mortality/aging
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N |
• mice are viable and survive to adulthood in contrast to mice without the transgene
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat/Slc18a3tm1.1Vpra mutation
(0 available);
any
Slc18a3 mutation
(11 available)
Tg(Chat-COP4*H134R/EYFP,Slc18a3)6Gfng mutation
(1 available)
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mortality/aging
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N |
• mice are viable and survive to adulthood in contrast to mice without the transgene
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Chat-COP4*H134R/EYFP,Slc18a3)6Gfng mutation
(1 available)
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behavior/neurological
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• mice did not improve performance in the cued version of Morris water maze
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• mice do not improve time spent or distance travelled on rotarod as compared to controls
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• mice visit target hole less than controls in Barnes maze test
• mice show no preference for target quadrant in Morris water maze during the probe trial, although they perform similar to controls in acquisition phase
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• mice revisit arms of Y-maze more often than controls, with less spontaneous alternations
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• mice consume more food and water during the dark cycle than controls
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• mice consume more food and water during the dark cycle than controls
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Chat-COP4*H134R/EYFP,Slc18a3)6Gfng mutation
(1 available)
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behavior/neurological
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• following a first injection of low dose D-amphetamine mice spent less time in slow versus fast locomotion and exhibited an increase in distance travelled as compared to wild-type
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• 20 minutes after injection with high dose D-amphetamine transgenic mice exhibit severe and confined stereotypic behaviors such as floor/wall sniffing
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nervous system
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• increased number of cholinergic interneurons, however, compartmental distribution of processes is similar to control
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• cholinergic neuropil of the striatum is denser than neuropil found in controls
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Analysis Tools
