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Allele Symbol Allele Name Allele ID |
Cd151tm2Nki targeted mutation 2, The Netherlands Cancer Institute MGI:4950443 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in keratinocytes infected with a cre-expressing adenovirus
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• in keratinocytes infected with a cre-expressing adenovirus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151tm2Nki/Cd151tm2Nki Krt14tm1(cre)Wbm mice
• however, overall benign and malignant histology is normal
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• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151tm2Nki/Cd151tm2Nki Krt14tm1(cre)Wbm mice
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• in papillomas of DMBA- and TPA-treated mice
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• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151tm2Nki/Cd151tm2Nki Krt14tm1(cre)Wbm mice
• however, overall benign and malignant histology is normal
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• in papillomas of DMBA- and TPA-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• keratinocytes expressing a hair bulge marker are found in the infundibulum and the interfollicular epidermis
• short-term TPA treatment increases the number of keratinocytes expressing a hair bulge marker found in the suprabasal layer
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• in papillomas of DMBA- and TPA-treated mice
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• contains fewer long-lived, slow-cycling label-retaining cells (keratinocytes expressing the hair bulge marker)
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• reduced tumor volume and incidents in DMBA- and TPA-treated mice compared with control mice
• however, overall benign and malignant histology is normal
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• reduced tumor volume and incidents in DMBA- and TPA-treated mice compared with control mice
• mildly decreases tumor progression of squamous cell carcinoma induced by DMBA and TPA
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• reduced tumor volume and incidents in DMBA- and TPA-treated mice compared with control mice
• however, overall benign and malignant histology is normal
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• keratinocytes expressing a hair bulge marker are found in the infundibulum and the interfollicular epidermis
• short-term TPA treatment increases the number of keratinocytes expressing a hair bulge marker found in the suprabasal layer
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• in papillomas of DMBA- and TPA-treated mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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