All Phenotypes Xist<tm5.2Nbd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Xist^tm5.2Nbd/Xist⁺	involves: 129P2/OlaHsd	MGI:4950465
cx2	Tg(CAG-EGFP)D4Nagy/0 Xist^tm5.2Nbd/Xist⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:4950463
ot3	Xist^tm5.2Nbd/Y	involves: 129P2/OlaHsd	MGI:4950464

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171502 )

• when the allele is paternally inherited, female mice die by E10.5

embryo

embryonic growth retardation ( J:171502 )

• at E7.5 in female embryos when the allele is paternally inherited

decreased embryo size ( J:171502 )

• at E8.5 and E9.5 in female embryos when the allele is paternally inherited

open neural tube ( J:171502 )

• when the allele is paternally inherited, E9.5 female mice exhibit incomplete caudal fusion unlike wild-type mice

absent placental labyrinth ( J:171502 )

• when the allele is paternally inherited, female mice fail to develop a placenta unlike wild-type male mice

growth/size/body

embryonic growth retardation ( J:171502 )

• at E7.5 in female embryos when the allele is paternally inherited

decreased embryo size ( J:171502 )

• at E8.5 and E9.5 in female embryos when the allele is paternally inherited

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:171502 )

• when the allele is paternally inherited, female mice fail to exhibit X-linked gene silencing compared with wild-type mice

nervous system

open neural tube ( J:171502 )

• when the allele is paternally inherited, E9.5 female mice exhibit incomplete caudal fusion unlike wild-type mice

Allelic Composition	Tg(CAG-EGFP)D4Nagy/0 Xist^tm5.2Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Xist^tm5.2Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:171502 )

• when the allele is maternally inherited, mice exhibit secondary non-random X inactivation compared with wild-type mice

Allelic Composition	Xist^tm5.2Nbd/Y
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm5.2Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:171502 )

• male mice fail to produce female offspring

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