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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nxf3tm1.1Jw
targeted mutation 1.1, Jeremy Wang
MGI:4950382
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nxf3tm1.1Jw/Nxf3tm1.1Jw involves: 129S4/SvJae * C57BL/6 MGI:4950398
cn2
 		Nxf2tm1.1JwNxf3tm1.1Jw/Y
Tg(Ddx4-cre)1Dcas/0 		involves: 129S4/SvJae * C57BL/6 * FVB MGI:5500935
cn3
 		Nxf2tm1.1JwNxf3tm1.1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5500932


Genotype
MGI:4950398
hm1
Allelic
Composition		 Nxf3tm1.1Jw/Nxf3tm1.1Jw
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf3tm1.1Jw mutation (1 available); any Nxf3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:171521 )
N
• mice are fertile




Genotype
MGI:5500935
cn2
Allelic
Composition		 Nxf2tm1.1JwNxf3tm1.1Jw/Y
Tg(Ddx4-cre)1Dcas/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf2tm1.1Jw mutation (1 available); any Nxf2 mutation (4 available)
Nxf3tm1.1Jw mutation (1 available); any Nxf3 mutation (10 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:199138 )
• less than 8% of wild-type
arrest of spermatogenesis ( J:199138 )
• the most advanced germ cells are at the pachytene stage

endocrine/exocrine glands

cellular
oligozoospermia ( J:199138 )
• less than 8% of wild-type




Genotype
MGI:5500932
cn3
Allelic
Composition		 Nxf2tm1.1JwNxf3tm1.1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf2tm1.1Jw mutation (1 available); any Nxf2 mutation (4 available)
Nxf3tm1.1Jw mutation (1 available); any Nxf3 mutation (10 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory