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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igh-8tm1.1Aak
targeted mutation 1.1, Ahmed Khamlichi
MGI:4950362
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igh-8tm1.1Aak/Igh-8tm1.1Aak involves: 129S2/SvPas * C57BL/6 MGI:4950370


Genotype
MGI:4950370
hm1
Allelic
Composition		 Igh-8tm1.1Aak/Igh-8tm1.1Aak
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-8tm1.1Aak mutation (0 available); any Igh-8 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:171251 )
• class switching to IgG3 is prevented
• class switching to IgG1 and IgG2b is normal

hematopoietic system
abnormal class switch recombination ( J:171251 )
• class switching to IgG3 is prevented
• class switching to IgG1 and IgG2b is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory