Phenotypes associated with this allele

• Allele Symbol: Ntrk3^tm1.1Tes
• Allele Name: targeted mutation 1.1, Lino Tessarollo
• Allele ID: MGI:4950053
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk3^tm1.1Tes/Ntrk3^tm1.1Tes	involves: 129S1/Sv	MGI:4950054
cx2	Ntrk3^tm1.1Tes/Ntrk3^+ Tg(RHO*P347S)A1Tili/0	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:6188005
cx3	Ntrk3^tm1.1Tes/Ntrk3^tm1.1Tes Tg(RHO*P347S)A1Tili/0	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:6188007

Genotype
MGI:4950054

hm1

• Allelic Composition: Ntrk3^tm1.1Tes/Ntrk3^tm1.1Tes
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:171397 )

N • development of glaucoma after right eye cauterization is normal

retina ganglion cell degeneration ( J:171397 )

• retinal ganglion cell development is normal in the absence of glaucoma

• resistant to retinal ganglion cell loss during glaucoma

• 20% loss after 5 weeks of glaucoma as compared to 36% loss in controls

nervous system

retina ganglion cell degeneration ( J:171397 )

• retinal ganglion cell development is normal in the absence of glaucoma

• resistant to retinal ganglion cell loss during glaucoma

• 20% loss after 5 weeks of glaucoma as compared to 36% loss in controls

Genotype
MGI:6188005

cx2

• Allelic Composition: Ntrk3^tm1.1Tes/Ntrk3⁺; Tg(RHO*P347S)A1Tili/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

vision/eye

thin retina outer nuclear layer ( J:262975 )

• as early as P18 to a lesser degree than in Tg(RHO*P347S)#Tili mice until P28

• however, mice exhibit normal nerve fiber, ganglion cell and inner plexiform layer thickness

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:262975

Genotype
MGI:6188007

cx3

• Allelic Composition: Ntrk3^tm1.1Tes/Ntrk3^tm1.1Tes; Tg(RHO*P347S)A1Tili/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

reproductive system

decreased litter size ( J:262975 )

vision/eye

abnormal eye morphology ( J:262975 )

• some mice do not open their eye lids normally compared with wild-type mice

microphthalmia ( J:262975 )

• some mice do not open their eye lids normally compared with wild-type mice

growth/size/body

decreased body weight ( J:262975 )

• low-weight offspring