Analysis Tools
mortality/aging
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• some mice die between E16.5 and E18.5
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• mice exhibiting exencephaly die shortly after birth due to central nervous system disorder unlike wild-type mice
• fewer than expected mice are present at weaning
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reproductive system
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• the number of spermatozoa in mutant male mice is reduced to about half of that in control males
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nervous system
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• at E18.5, exencephalic mice exhibit bleeding from the brain unlike wild-type mice
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• at E9.5, mice exhibit a 3-fold increase in apoptosis in the neuroepithelium unlike wild-type mice
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• at E14.5, mice exhibit increased neural progenitor cell proliferation compared with wild-type mice
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• at E9.5 and E10.5, the neural folds remain unfused, unlike in wild-type embryos
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• Background Sensitivity: on a 129P2/OlaHsd and C57BL/6 background, some mice exhibit failure of neural tube closure in the midbrain and hindbrain unlike wild-type mice
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• the midbrain and hindbrain are massively expanded and everted and cover the whole brain unlike in wild-type mice
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• the midbrain and hindbrain are massively expanded and everted and cover the whole brain unlike in wild-type mice
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• absent
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exencephaly
(
J:171291
)
vision/eye
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• mice exhibit expanded neural retina compared with wild-type mice
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• in some mice at E14.5
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growth/size/body
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• at E9.5, mice exhibit a 3-fold increase in apoptosis in the cranial mesenchyme unlike wild-type mice
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• in adult mice
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• in exencephalic mice at E18.5
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cellular
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• the number of spermatozoa in mutant male mice is reduced to about half of that in control males
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• at E9.5, mice exhibit a 3-fold increase in apoptosis in the cranial mesenchyme unlike wild-type mice
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• at E9.5, mice exhibit a 3-fold increase in apoptosis in the neuroepithelium unlike wild-type mice
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• at E14.5, mice exhibit increased neural progenitor cell proliferation compared with wild-type mice
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limbs/digits/tail
curly tail
(
J:171291
)
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• in some mice
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cardiovascular system
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• at E18.5, exencephalic mice exhibit bleeding from the brain unlike wild-type mice
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embryo
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• at E9.5, mice exhibit a 3-fold increase in apoptosis in the cranial mesenchyme unlike wild-type mice
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• at E9.5 and E10.5, the neural folds remain unfused, unlike in wild-type embryos
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• Background Sensitivity: on a 129P2/OlaHsd and C57BL/6 background, some mice exhibit failure of neural tube closure in the midbrain and hindbrain unlike wild-type mice
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