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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnu1tm1.1Clin
targeted mutation 1.1, Christopher J Lingle
MGI:4949762
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnu1tm1.1Clin/Kcnu1tm1.1Clin involves: C57BL/6 * C57BL/6NTac * SJL MGI:4949839
ht2
 		Kcnu1tm1.1Clin/Kcnu1+ involves: C57BL/6NTac MGI:5896620


Genotype
MGI:4949839
hm1
Allelic
Composition		 Kcnu1tm1.1Clin/Kcnu1tm1.1Clin
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnu1tm1.1Clin mutation (1 available); any Kcnu1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:171225 )
N
• mice exhibit normal fertility
abnormal sperm physiology ( J:171225 )
• some alkalization-activated potassium ion current is abolished in spermatozoa unlike in wild-type cells




Genotype
MGI:5896620
ht2
Allelic
Composition		 Kcnu1tm1.1Clin/Kcnu1+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnu1tm1.1Clin mutation (1 available); any Kcnu1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:220171 )
N
• male fertility is similar to controls
abnormal sperm physiology ( J:220171 )
• KSPER conductance is reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory