Phenotypes associated with this allele

• Allele Symbol: Cacna1a^tm1.2Sher
• Allele Name: targeted mutation 1.2, Stefan Herlitze
• Allele ID: MGI:4949729
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1a^tm1.2Sher/Cacna1a^tm1.2Sher	involves: 129S4/SvJae	MGI:4949732

Genotype
MGI:4949732

hm1

• Allelic Composition: Cacna1a^tm1.2Sher/Cacna1a^tm1.2Sher
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:170451 )

• mice die 3 to 4 weeks after birth

behavior/neurological

ataxia ( J:170451 )

seizures ( J:170451 )

• severe

nervous system

seizures ( J:170451 )

• severe

abnormal inhibitory postsynaptic current amplitude ( J:170451 )

• omegaAgalVA-treatment fails to reduce inhibitory postsynaptic current (IPSC) amplitudes unlike in similarly treated wild-type mice

• however, response to omega CtxGVIA is normal

growth/size/body

decreased body size ( J:170451 )