Phenotypes associated with this allele

• Allele Symbol: Grn^tm1Far
• Allele Name: targeted mutation 1, Bob Farese
• Allele ID: MGI:4949109
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Grn^tm1Far/Grn^tm1Far	involves: 129S4/SvJae * C57BL/6J * FVB/N	MGI:5444202
cn2	Grn^tm1Far/Grn^tm1Far Tg(ITGAM-cre)2781Gkl/0	involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N	MGI:5444201

Genotype
MGI:5444202

cn1

• Allelic Composition: Grn^tm1Far/Grn^tm1Far
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron physiology ( J:188324 )

• following treated with LPS and IFN-gamma, primary cultures from mice infected a lentivirus expressing cre in microglia exhibit increased neuron death compared with controls

Genotype
MGI:5444201

cn2

• Allelic Composition: Grn^tm1Far/Grn^tm1Far; Tg(ITGAM-cre)2781Gkl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

nervous system

microgliosis ( J:188324 )

• in MPTP-treated mice

increased susceptibility to dopaminergic neuron neurotoxicity ( J:188324 )

• induced by MPTP

loss of dopaminergic neurons ( J:188324 )

• greater in mice treated with MPTP compared with control mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:188324 )

• induced by MPTP

cellular

microgliosis ( J:188324 )

• in MPTP-treated mice

increased susceptibility to dopaminergic neuron neurotoxicity ( J:188324 )

• induced by MPTP

hematopoietic system

microgliosis ( J:188324 )

• in MPTP-treated mice

immune system

microgliosis ( J:188324 )

• in MPTP-treated mice