Phenotypes associated with this allele

• Allele Symbol: Rheb^tm1.1Yelg
• Allele Name: targeted mutation 1.1, Ype Elgersma
• Allele ID: MGI:4949062
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rheb^tm1.1Yelg/Rheb^tm1.1Yelg	B6.129P2-Rheb^tm1.1Yelg	MGI:4949083
cx2	Rheb^tm1.1Yelg/Rheb^+ Tsc1^tm1Chdl/Tsc1^tm1Chdl	B6.129P2-Tsc1^tm1Chdl Rheb^tm1.1Yelg	MGI:4949084

Genotype
MGI:4949083

hm1

• Allelic Composition: Rheb^tm1.1Yelg/Rheb^tm1.1Yelg
• Genetic Background: B6.129P2-Rheb^tm1.1Yelg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:170999 )

• mice die around E12.5 probably due to circulatory failure secondary to poor heart development

cardiovascular system

abnormal heart development ( J:170999 )

• impaired

thin ventricular wall ( J:170999 )

• pointing toward cardiorrhexis

hemopericardium ( J:170999 )

• in 2 of 3 mice

cellular

increased embryonic tissue cell apoptosis ( J:170999 )

• embryos exhibit increased patches of apoptosis, particularly in the liver, unlike wild-type mice

embryo tissue necrosis ( J:170999 )

• in embryos

decreased fibroblast proliferation ( J:170999 )

• mouse embryonic fibroblasts hardly proliferate compared with wild-type cells

embryo

increased embryonic tissue cell apoptosis ( J:170999 )

• embryos exhibit increased patches of apoptosis, particularly in the liver, unlike wild-type mice

embryo tissue necrosis ( J:170999 )

• in embryos

embryonic growth retardation ( J:170999 )

decreased embryo size ( J:170999 )

• at E10.5 and E12.5

homeostasis/metabolism

hemopericardium ( J:170999 )

• in 2 of 3 mice

growth/size/body

embryonic growth retardation ( J:170999 )

decreased embryo size ( J:170999 )

• at E10.5 and E12.5

Genotype
MGI:4949084

cx2

• Allelic Composition: Rheb^tm1.1Yelg/Rheb⁺; Tsc1^tm1Chdl/Tsc1^tm1Chdl
• Genetic Background: B6.129P2-Tsc1^tm1Chdl Rheb^tm1.1Yelg

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:170999 )

• mice die between E15.5 and birth unlike Tsc1^tm1Chdl heterozygotes which die between E10.5 and E13.5

growth/size/body

decreased fetal size ( J:170999 )

• at E15.5

fetal growth retardation ( J:170999 )

• at E15.5

cellular

increased embryonic tissue cell apoptosis ( J:170999 )

• in E15.5 embryos

embryo

increased embryonic tissue cell apoptosis ( J:170999 )

• in E15.5 embryos