All Phenotypes Keap1<tm1.1Sbis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Keap1^tm1.1Sbis
targeted mutation 1.1, Shyam Biswal
MGI:4948838

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Keap1^tm1.1Sbis/Keap1^tm1.1Sbis Tg(Scgb1a1-cre)1Grau/0	involves: C57BL/6J	MGI:4948839

Allelic Composition	Keap1^tm1.1Sbis/Keap1^tm1.1Sbis Tg(Scgb1a1-cre)1Grau/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Keap1^tm1.1Sbis mutation (1 available); any Keap1 mutation (34 available)
Tg(Scgb1a1-cre)1Grau mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung epithelium morphology ( J:170960 )

• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells

abnormal club cell morphology ( J:170960 )

• Clara cells exposed to hydrogen peroxide exhibit lower levels of reactive oxygen species compared with similarly-treated wild-type cells

homeostasis/metabolism

decreased susceptibility to injury ( J:170960 )

• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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