Phenotypes associated with this allele

• Allele Symbol: Map1s^tm1.1Lliu
• Allele Name: targeted mutation 1.1, Leyuan Liu
• Allele ID: MGI:4948361
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map1s^tm1.1Lliu/Map1s^tm1.1Lliu	involves: 129S4/SvJaeSor * C57BL/6	MGI:4948442
cx2	Map1s^tm1.1Lliu/Map1s^tm1.1Lliu Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj	MGI:4948445

Genotype
MGI:4948442

hm1

• Allelic Composition: Map1s^tm1.1Lliu/Map1s^tm1.1Lliu
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:170757 )

• cells exhibit defective autophagosome biogenesis compared with cells from wild-type mice

reproductive system

reproductive system phenotype ( J:170757 )

N • mice exhibit normal reproduction

cardiovascular system

abnormal myocardial fiber morphology ( J:170757 )

• cardiomyocytes in neonates and adult exhibit a 3-fold increase in dysfunctional mitochondria compared with wild-type mice

cellular

abnormal autophagosome formation ( J:170757 )

• cells exhibit defective autophagosome biogenesis compared with cells from wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:170757 )

N • mice exhibit normal behavior

muscle

abnormal myocardial fiber morphology ( J:170757 )

• cardiomyocytes in neonates and adult exhibit a 3-fold increase in dysfunctional mitochondria compared with wild-type mice

Genotype
MGI:4948445

cx2

• Allelic Composition: Map1s^tm1.1Lliu/Map1s^tm1.1Lliu; Tg(CAG-EGFP/Map1lc3b)53Nmz/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:170757 )

• starved neonates survival time is half that of similarly treated wild-type mice

cellular

abnormal autophagy ( J:170757 )

• heart and liver tissues from pups under nutritive stress exhibit early accumulation of autophagosomes associated with impaired autophagosomal degradation compared with tissues form wild-type mice

homeostasis/metabolism

abnormal autophagy ( J:170757 )

• heart and liver tissues from pups under nutritive stress exhibit early accumulation of autophagosomes associated with impaired autophagosomal degradation compared with tissues form wild-type mice