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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pkd1l1rks
rikishi
MGI:4948351
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pkd1l1rks/Pkd1l1rks C3H.B6-Pkd1l1rks MGI:4948352
ht2
 		Pkd1l1rks/Pkd1l1+ C3H.B6-Pkd1l1rks MGI:4948353
cx3
 		Pkd1l1rks/Pkd1l1+
Pkd2lrm4/Pkd2+ 		C3.Cg-Pkd2lrm4 Pkd1l1rks MGI:4948354


Genotype
MGI:4948352
hm1
Allelic
Composition		 Pkd1l1rks/Pkd1l1rks
Genetic
Background		 C3H.B6-Pkd1l1rks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1l1rks mutation (0 available); any Pkd1l1 mutation (155 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:170490 )
• most embryos die by E15.5 and the few remaining embryos are developmentally delayed and close to death

embryo
embryo phenotype ( J:170490 )
N
• embryonic node cilia motion appears normal
abnormal direction of embryo turning ( J:170490 )
• at E9.5 embryos display normal, inverted or indifferent turning
abnormal left-right axis patterning ( J:170490 )
• expression analysis detects defect in left-right asymmetry of the lateral plate mesoderm
embryonic growth arrest ( J:170490 )
• arrest around E14.5
embryonic growth retardation ( J:170490 )
• the few embryos alive at E15.5 are developmentally delayed

homeostasis/metabolism
edema ( J:170490 )
• in 25 of 28 embryos at E13.5 - E14.5

growth/size/body
right-sided stomach ( J:170490 )
• in some embryos at E13.5 - E14.5
embryonic growth retardation ( J:170490 )
• the few embryos alive at E15.5 are developmentally delayed
right pulmonary isomerism ( J:170490 )
• seen in all embryos

cardiovascular system
dextrocardia ( J:170490 )
• in some embryos at E13.5 - E14.5

digestive/alimentary system
right-sided stomach ( J:170490 )
• in some embryos at E13.5 - E14.5

respiratory system
right pulmonary isomerism ( J:170490 )
• seen in all embryos




Genotype
MGI:4948353
ht2
Allelic
Composition		 Pkd1l1rks/Pkd1l1+
Genetic
Background		 C3H.B6-Pkd1l1rks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1l1rks mutation (0 available); any Pkd1l1 mutation (155 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:170490 )
N
• unlike in mice heterozygous for null alleles of Pkd1 or Pkd2, no kidney cysts are detected in mice at up to 18 months of age




Genotype
MGI:4948354
cx3
Allelic
Composition		 Pkd1l1rks/Pkd1l1+
Pkd2lrm4/Pkd2+
Genetic
Background		 C3.Cg-Pkd2lrm4 Pkd1l1rks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1l1rks mutation (0 available); any Pkd1l1 mutation (155 available)
Pkd2lrm4 mutation (0 available); any Pkd2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:170490 )
• no abnormal kidney, cardiac or situs pathology is detected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory