Phenotypes associated with this allele

• Allele Symbol: Cdc14b^tm1.2Pzg
• Allele Name: targeted mutation 1.2, Pumin Zhang
• Allele ID: MGI:4948253
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc14b^tm1.2Pzg/Cdc14b^tm1.2Pzg	B6.129P2-Cdc14b^tm1.2Pzg	MGI:4948269
hm2	Cdc14b^tm1.2Pzg/Cdc14b^tm1.2Pzg	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6694868

Genotype
MGI:4948269

hm1

• Allelic Composition: Cdc14b^tm1.2Pzg/Cdc14b^tm1.2Pzg
• Genetic Background: B6.129P2-Cdc14b^tm1.2Pzg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature aging ( J:170763 )

• including premature cataracts and kyphosis

reproductive system

reduced fertility ( J:170763 )

• particularly from female mice

reduced female fertility ( J:170763 )

♀

decreased litter size ( J:170763 )

• particularly from female mice

reduced male fertility ( J:170763 )

♂

vision/eye

abnormal cornea morphology ( J:170763 )

• mice exhibit loose and thickened cornea compared with wild-type mice

increased cornea thickness ( J:170763 )

corneal opacity ( J:170763 )

abnormal lens morphology ( J:170763 )

• mice exhibit invaginations in the ocular lens compared with wild-type mice

cataract ( J:170763 )

• premature

cellular

cellular phenotype ( J:170763 )

N • mouse embryonic fibroblasts exhibit normal DNA damage checkpoints

early cellular replicative senescence ( J:170763 )

• in mouse embryonic fibroblasts

abnormal DNA repair ( J:170763 )

• mouse embryonic fibroblasts exhibit defective DNA damage repair compared with wild-type cells

behavior/neurological

behavior/neurological phenotype ( J:170763 )

N • mice exhibit normal cued conditioning

impaired contextual conditioning behavior ( J:170763 )

skeleton

kyphosis ( J:170763 )

• premature

homeostasis/metabolism

abnormal DNA repair ( J:170763 )

• mouse embryonic fibroblasts exhibit defective DNA damage repair compared with wild-type cells

Genotype
MGI:6694868

hm2

• Allelic Composition: Cdc14b^tm1.2Pzg/Cdc14b^tm1.2Pzg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:257652 )

N • mice exhibit normal hearing at P30-P90, as determined by ABR thresholds

reproductive system

reproductive system phenotype ( J:257652 )

N • both males and females are reported to be fertile