Phenotypes associated with this allele

• Allele Symbol: Gpr88^{tm1.1(cre/GFP)Rpa}
• Allele Name: targeted mutation 1.1, Richard D Palmiter
• Allele ID: MGI:4947986
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr88^tm1.1(cre/GFP)Rpa/Gpr88^tm1.1(cre/GFP)Rpa	involves: 129S4/SvJaeSor * C57BL/6	MGI:6201721

Genotype
MGI:6201721

hm1

• Allelic Composition: Gpr88^{tm1.1(cre/GFP)Rpa}/Gpr88^{tm1.1(cre/GFP)Rpa}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:193543 )

• exposure to SKF-82197 (a D1R agonist) increases locomotion more in wild-type mice than in homozygous mutants

• quinpirole (a D2R agonist) increases, rather than decreases, locomotion in mutants

enhanced behavioral response to amphetamine ( J:193543 )

• have a greater locomotion response after repeated exposure to amphetamine

abnormal associative learning ( J:193543 )

• higher latencies to reach the decision point and platform in a water based U-maze

• however, the percentage of correct choices in a U-maze is similar to controls

impaired active avoidance behavior ( J:193543 )

• acquisition of a two-way active avoidance task is impaired

• however, latency to escape after foot shock or sound cue is not different from controls in the first 10 trials indicating no decrease in pain sensitivity or motor function

impaired cued conditioning behavior ( J:193543 )

• in a cued-based strategy test, mice are slower to learn the escape strategy and have higher latencies to reach the platform

abnormal motor learning ( J:193543 )

• show no improvement in rotarod performance with training

increased exploration in new environment ( J:193543 )

• locomotor activity is higher in the first few hours in an activity chamber

impaired coordination ( J:193543 )

• fall off a rotarod more quickly compared to controls

decreased grip strength ( J:193543 )

• shorter latency to fall from an inverted wire mesh compared to wild-type controls

hyperactivity ( J:193543 )

• increase in activity during the nocturnal cycle is greater than in wild-type controls

• however, daytime activity levels are similar to controls

nervous system

abnormal nervous system electrophysiology ( J:193543 )

• medium spiny neuron have a higher average firing rate and an increased percentage of medium spiny neurons show continuous rather than burst firing

abnormal neuron physiology ( J:193543 )

• input resistance is increased in dorsal medium spiny neurons in striatal slices

abnormal GABA-mediated receptor currents ( J:193543 )

• baseline tonic GABA currents in medium spiny neurons are reduced

abnormal excitatory postsynaptic currents ( J:193543 )

• the stimulation threshold to evoke an EPSC is lower in medium spiny neurons

increased excitatory postsynaptic current amplitude ( J:193543 )

• mean peak response amplitude is increased at stimulation intensities greater than 0.6 mA in medium spiny neurons

abnormal inhibitory postsynaptic currents ( J:193543 )

• peak evoked inhibitory postsynaptic currents are suppressed in medium spiny neurons

• increase in the mean stimulation current required to evoke an IPSC in medium spiny neurons