Phenotypes associated with this allele

• Allele Symbol: Kat7^tm1.2Avo
• Allele Name: targeted mutation 1.2, Anne K Voss
• Allele ID: MGI:4947692
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat7^tm1.2Avo/Kat7^tm1.2Avo	involves: C57BL/6	MGI:4947715

Genotype
MGI:4947715

hm1

• Allelic Composition: Kat7^tm1.2Avo/Kat7^tm1.2Avo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:170405 )

• no mice are recovered after E10.5

cardiovascular system

abnormal blood vessel morphology ( J:170405 )

• at E8.5, mice develop enlarged blood vessels in the head region unlike in wild-type mice

abnormal cardiovascular development ( J:170405 )

• mice exhibit cardiac inflow tract dilation compared with wild-type mice

dilated dorsal aorta ( J:170405 )

abnormal first pharyngeal arch artery morphology ( J:170405 )

• dilated lumina

disorganized yolk sac vascular plexus ( J:170405 )

absent heartbeat ( J:170405 )

• in 9 of 18 mice at E11.5

embryo

abnormal first pharyngeal arch artery morphology ( J:170405 )

• dilated lumina

disorganized yolk sac vascular plexus ( J:170405 )

increased embryonic tissue cell apoptosis ( J:170405 )

• 8-fold in embryos

incomplete embryo turning ( J:170405 )

embryonic growth arrest ( J:170405 )

• at 10- to 11-somite stage

embryonic growth retardation ( J:170405 )

• at 10- to 11-somite stage

abnormal somite development ( J:170405 )

• somites are indistinct and unstructured unlike in wild-type mice

failure of chorioallantoic fusion ( J:170405 )

abnormal vitelline vascular remodeling ( J:170405 )

• vascular branching and patterning in the highly disorganized yolk sac compared to in wild-type mice

cellular

cellular phenotype ( J:170405 )

N • cell proliferation and DNA replication is normal

increased embryonic tissue cell apoptosis ( J:170405 )

• 8-fold in embryos

craniofacial

abnormal first pharyngeal arch artery morphology ( J:170405 )

• dilated lumina

growth/size/body

embryonic growth retardation ( J:170405 )

• at 10- to 11-somite stage