All Phenotypes Topbp1<tm1.1Dsh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Topbp1^tm1.1Dsh
targeted mutation 1.1, Deog Su Hwang
MGI:4947431

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Topbp1^tm1.1Dsh/Topbp1^tm1.1Dsh	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:4947433
cn2	Topbp1^tm1.1Dsh/Topbp1^tm1.1Dsh	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:4947434

Allelic Composition	Topbp1^tm1.1Dsh/Topbp1^tm1.1Dsh
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Topbp1^tm1.1Dsh mutation (0 available); any Topbp1 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:170406 )

• mice are viable and fertile

Allelic Composition	Topbp1^tm1.1Dsh/Topbp1^tm1.1Dsh
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Topbp1^tm1.1Dsh mutation (0 available); any Topbp1 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:170406 )

• fibroblasts transfected with a cre-expressing retrovirus exhibit increased activation of DNA damage signaling compared with wild-type cells

abnormal cell cycle ( J:170406 )

• fibroblasts transfected with a cre-expressing retrovirus exhibit arrest during progression of the cell cycle unlike wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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