Phenotypes associated with this allele

• Allele Symbol: Csgalnact1^tm1.1Nari
• Allele Name: targeted mutation 1.1, Hisashi Narimatsu
• Allele ID: MGI:4947395
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csgalnact1^tm1.1Nari/Csgalnact1^tm1.1Nari	involves: C57BL/6J	MGI:4947396
cx2	Csgalnact1^tm1.1Nari/Csgalnact1^tm1.1Nari Csgalnact2^tm1.2Staka/Csgalnact2^tm1.2Staka	involves: C57BL/6J	MGI:6117388

Genotype
MGI:4947396

hm1

• Allelic Composition: Csgalnact1^tm1.1Nari/Csgalnact1^tm1.1Nari
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:170410 )

N • mice exhibit a normal lifespan

reproductive system

reproductive system phenotype ( J:170410 )

N • mice exhibit normal reproduction

skeleton

skeleton phenotype ( J:170410 )

N • mice exhibit normal chondrocyte proliferation and differentiation

short humerus ( J:170410 )

short tibia ( J:170410 )

abnormal cartilage morphology ( J:170410 , J:256718 )

• humerus cartilage exhibit decreased extracellular matrix and densely packed proliferative chondrocytes compared to in wild-type mice (J:170410)

• Safranin-O staining indicates slightly decreased glycosaminoglycan content (J:256718)

• reduced chondroitin sulfate content (J:256718)

abnormal long bone epiphyseal plate proliferative zone ( J:170410 )

• mice exhibit decreased proliferative chondrocytes compared to in wild-type mice

decreased long bone epiphyseal plate size ( J:170410 )

disorganized long bone epiphyseal plate ( J:170410 )

• chondrocyte columns are disorganized compared to in wild-type mice

growth/size/body

proportional dwarf ( J:170410 )

• a few days after birth

postnatal growth retardation ( J:170410 )

limbs/digits/tail

short humerus ( J:170410 )

short tibia ( J:170410 )

Genotype
MGI:6117388

cx2

• Allelic Composition: Csgalnact1^tm1.1Nari/Csgalnact1^tm1.1Nari; Csgalnact2^tm1.2Staka/Csgalnact2^tm1.2Staka
• Genetic Background: involves: C57BL/6J

mortality/aging

neonatal lethality, complete penetrance ( J:256718 )

• do not survive after birth

respiratory system

respiratory distress ( J:256718 )

• when delivered by cesarean section pups struggle to initiate breathing

respiratory failure ( J:256718 )

• no alveolar air spaces in the lungs indicating mice die of respiratory failure

homeostasis/metabolism

cyanosis ( J:256718 )

growth/size/body

decreased birth body size ( J:256718 )

decreased birth weight ( J:256718 )

• slightly lower

skeleton

short humerus ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote

short tibia ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote

abnormal cartilage morphology ( J:256718 )

• Safranin-O staining indicates drastically decreased glycosaminoglycan content

limbs/digits/tail

short humerus ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote

short tibia ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote