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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Camk2a-cre)#Stl
transgene insertion, Susumu Tonegawa
MGI:4946944
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lztfl1tm1.2Zpl/Lztfl1tm1.2Zpl
Tg(Camk2a-cre)#Stl/0 		involves: 129S4/SvJaeSor * BALB/c * C57BL * C57BL/6 * C57BL/6N MGI:7435346
cn2
 		Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Camk2a-cre)#Stl/0 		involves: BALB/c * C57BL MGI:5517374
cn3
 		Gsk3atm1.1Tac/Gsk3atm1.1Tac
Tg(APPV717F)109Ili/0
Tg(Camk2a-cre)#Stl/0 		involves: BALB/c * C57BL * C57BL/6NTac MGI:5427914


Genotype
MGI:7435346
cn1
Allelic
Composition		 Lztfl1tm1.2Zpl/Lztfl1tm1.2Zpl
Tg(Camk2a-cre)#Stl/0
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/c * C57BL * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lztfl1tm1.2Zpl mutation (0 available); any Lztfl1 mutation (19 available)
Tg(Camk2a-cre)#Stl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal interlobular bile duct morphology ( J:287261 )
• mice show enlarged interlobular ducts
abnormal pancreas morphology ( J:287261 )
• pancreatic hypertrophy with enlarged islets and interlobular ducts
pancreatic islet hyperplasia ( J:287261 )
• mice show enlarged islets

growth/size/body
obese ( J:287261 )
• mice develop obesity in adulthood

homeostasis/metabolism
impaired glucose tolerance ( J:287261 )
• adults show delayed clearance of oral glucose in the oral glucose tolerance test
insulin resistance ( J:287261 )
• adults show decreased insulin sensitivity in the insulin tolerance test

liver/biliary system
abnormal interlobular bile duct morphology ( J:287261 )
• mice show enlarged interlobular ducts
hepatic steatosis ( J:287261 )
• livers exhibit extensive microvesicular and macrovesicular steatosis




Genotype
MGI:5517374
cn2
Allelic
Composition		 Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Camk2a-cre)#Stl/0
Genetic
Background		 involves: BALB/c * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2c2tm1Bbm mutation (0 available); any Nr2c2 mutation (67 available)
Tg(Camk2a-cre)#Stl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:197895 )
N
• mice exhibit normal pain and itch behaviors

nervous system
nervous system phenotype ( J:197895 )
N
• mice exhibit normal spinal cord organization




Genotype
MGI:5427914
cn3
Allelic
Composition		 Gsk3atm1.1Tac/Gsk3atm1.1Tac
Tg(APPV717F)109Ili/0
Tg(Camk2a-cre)#Stl/0
Genetic
Background		 involves: BALB/c * C57BL * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3atm1.1Tac mutation (0 available); any Gsk3a mutation (18 available)
Tg(APPV717F)109Ili mutation (0 available)
Tg(Camk2a-cre)#Stl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:184975 )
• significant decrease in amyloid beta senile plaques compared to transgenic mice wild-type for Gsk3a

behavior/neurological
behavior/neurological phenotype ( J:184975 )
N
• performance in a Barnes maze and in an open field are similar to wild-type controls unlike transgenic mice wild-type for Gsk3a

homeostasis/metabolism
amyloid beta deposits ( J:184975 )
• significant decrease in amyloid beta senile plaques compared to transgenic mice wild-type for Gsk3a




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory