All Phenotypes Slc6a4<tm1.1Rbl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc6a4^tm1.1Rbl
targeted mutation 1.1, Randy D Blakely
MGI:4946603

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a4^tm1.1Rbl/Slc6a4^tm1.1Rbl	129S6/SvEvTac-Slc6a4^tm1.1Rbl	MGI:4946606

Allelic Composition	Slc6a4^tm1.1Rbl/Slc6a4^tm1.1Rbl
Genetic Background	129S6/SvEvTac-Slc6a4^tm1.1Rbl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4^tm1.1Rbl mutation (2 available); any Slc6a4 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:170356 )

• mice exhibit reduced sensitivity to serotonin antagonists (fluoxetine, cocaine, citalopram, and escitalopram) compared with wild-type mice

• serotonergic neurons exhibit diminished inhibition mediated by selective serotonin re-uptake inhibitors (SSRI) compared with wild-type neurons

behavior/neurological

impaired behavioral response to xenobiotic ( J:170356 )

• mice treated with citalopram, fluoxetine, or paroxetine exhibit reduced impact on behavior in a tail suspension test and forced swim test compared with wild-type mice

nervous system

abnormal neuron physiology ( J:170356 )

• serotonergic neurons exhibit diminished inhibition mediated by selective serotonin re-uptake inhibitors (SSRI) compared with wild-type neurons

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