All Phenotypes Mtf2<tm1.1Hko> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mtf2^tm1.1Hko
targeted mutation 1.1, Haruhiko Koseki
MGI:4946491

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko	B6.Cg-Mtf2^tm1.1Hko	MGI:4946503
cx2	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Pcgf2^tm1Hko/Pcgf2^tm1Hko	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4946506
cx3	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Phc2^tm1Hko/Phc2^tm1Hko	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4946507
cx4	Mtf2^tm1.1Hko/Mtf2⁺ Phc2^tm1Hko/Phc2^tm1Hko	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4946508
cx5	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Suz12^tm1Hko/Suz12⁺	involves: C57BL/6	MGI:4946505

Allelic Composition	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko
Genetic Background	B6.Cg-Mtf2^tm1.1Hko

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf2^tm1.1Hko mutation (0 available); any Mtf2 mutation (314 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternum morphology ( J:170279 )

• shifted anteriorly

increased rib number ( J:170279 )

• mice exhibit ectopic ribs on the seventh cervical vertebrae unlike wild-type mice

abnormal odontoid process morphology ( J:170279 )

• on the first cervical vertebrae

vertebral transformation ( J:170279 )

• mice exhibit posterior transformation at thoracolumbar and lumbosacral transitions unlike wild-type mice

thoracic vertebral transformation ( J:170279 )

• 30% of mice exhibit T2 to T1 transformation

• 50% of mice exhibit T6 to T7 transformation

• 50% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• mice exhibit ectopic ribs on the seventh cervical vertebrae unlike wild-type mice

• 50% of mice exhibit a C1 to C2 transformation

• 60% of mice exhibit a C3 to C2 transformation

• 40% of mice exhibit C7 to T1 transformation

lumbar vertebral transformation ( J:170279 )

• 40% of mice exhibit L6 to S1 transformation

cellular

delayed cellular replicative senescence ( J:170279 )

• in mouse embryonic fibroblasts

Allelic Composition	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Pcgf2^tm1Hko/Pcgf2^tm1Hko
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf2^tm1.1Hko mutation (0 available); any Mtf2 mutation (314 available)
Pcgf2^tm1Hko mutation (2 available); any Pcgf2 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:170279 )

• no mice are observed at the perinatal stage

skeleton

abnormal occipital bone morphology ( J:170279 )

• segmented, forming an ectopic arch

abnormal supraoccipital bone morphology ( J:170279 )

• 90% of mice exhibit supraoccipital bone to C1 transformation

scapular bone foramen ( J:170279 )

increased rib number ( J:170279 )

• C7 forms perfect ribs

vertebral transformation ( J:170279 )

• at E16.5, homeotic transformations are more stringent than in single homozygotes

thoracic vertebral transformation ( J:170279 )

• 70% of mice exhibit T8 to T9 transformation

• 90% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• C1 is identical to C2 unlike in wild-type mice

• C7 forms perfect ribs

• 70% of mice exhibit C2 to C3 transformation

lumbar vertebral transformation ( J:170279 )

• 100% of mice exhibit L6 to S1 transforamtion

craniofacial

abnormal occipital bone morphology ( J:170279 )

• segmented, forming an ectopic arch

abnormal supraoccipital bone morphology ( J:170279 )

• 90% of mice exhibit supraoccipital bone to C1 transformation

Allelic Composition	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Phc2^tm1Hko/Phc2^tm1Hko
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf2^tm1.1Hko mutation (0 available); any Mtf2 mutation (314 available)
Phc2^tm1Hko mutation (1 available); any Phc2 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:170279 )

• mice exhibit late-gestational lethality

skeleton

abnormal supraoccipital bone morphology ( J:170279 )

• 90% of mice exhibit supraoccipital bone to C1 transformation

thoracic vertebral transformation ( J:170279 )

• 60% of mice exhibit T8 to T9 transformation

• 80% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• 100% of mice exhibit C1 to C2 transformation

• 40% of mice exhibit C2 to C3 transformation

• 100% of mice exhibit C7 to T1 transformation

lumbar vertebral transformation ( J:170279 )

• 100% of mice exhibit L6 to S1 transformation

cellular

early cellular replicative senescence ( J:170279 )

• in mouse embryonic fibroblasts

craniofacial

abnormal supraoccipital bone morphology ( J:170279 )

• 90% of mice exhibit supraoccipital bone to C1 transformation

Allelic Composition	Mtf2^tm1.1Hko/Mtf2⁺ Phc2^tm1Hko/Phc2^tm1Hko
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:170279 )

• mice exhibit late-gestational lethality

skeleton

abnormal skeleton morphology ( J:170279 )

Allelic Composition	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Suz12^tm1Hko/Suz12⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf2^tm1.1Hko mutation (0 available); any Mtf2 mutation (314 available)
Suz12^tm1Hko mutation (0 available); any Suz12 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternum morphology ( J:170279 )

• shifted anteriorly

increased rib number ( J:170279 )

• perfect ribs are associated with C7

vertebral transformation ( J:170279 )

• homeotic transformation is enhanced compared to in Mtf2^tm1.1Hko homozygotes

thoracic vertebral transformation ( J:170279 )

• unlike in wild-type mice, a prominent spinous process is associated with T1 instead of T2

• 75% of mice exhibit T1 to T2 transformation

• 75% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• unlike in wild-type mice, anterior tuberculums are associated with C5 instead of C6 and perfect ribs are associated with C7

• 25% of mice exhibit C1 to C2 transforamtion

• 42% of mice exhibit C2 to C3 transformation

• 42% of mice exhibit C5 to C6 transformation

• 58% of mice exhibit C6 to T1 transformation

lumbar vertebral transformation ( J:170279 )

• 92% of mice exhibit L6 to S1 transformation

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