Phenotypes associated with this allele

• Allele Symbol: Trarg1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4944413
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trarg1^tm1a(KOMP)Wtsi/Trarg1^tm1a(KOMP)Wtsi	C57BL/6N-Trarg1^tm1a(KOMP)Wtsi	MGI:5800431

Genotype
MGI:5800431

hm1

• Allelic Composition: Trarg1^{tm1a(KOMP)Wtsi}/Trarg1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Trarg1^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0757_5_F08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased adipocyte glucose uptake ( J:234039 )

• primary adipocytes derived from mutant inguinal white adipose tissue (iWAT), epididymal WAT, and brown adipose tissue (BAT) show a significantly reduced glucose uptake in response to an insulin stimulus relative to wild-type controls

• following rosiglitazone treatment, primary white and brown adipocytes from mutant mice fail to exhibit improved insulin-mediated glucose uptake, unlike similarly treated wild-type adipocytes

growth/size/body

increased body weight ( J:234039 )

• on a high-fat diet (HFD), mice show a trend towards increased weight gain relative to wild-type controls

• fat pad weights and total body adiposity are not significantly altered on a HFD

• chow-fed mice exhibit normal body weight relative to wild-type controls

homeostasis/metabolism

abnormal fasting circulating glucose level ( J:234039 )

• following rosiglitazone treatment, HFD-fed mice show a significantly smaller reduction in fasting blood glucose levels relative to wild-type controls (19% versus 33%, respectively

hyperglycemia ( J:234039 )

• after 12 weeks of HFD, mice exhibit significantly elevated re-fed blood glucose levels relative to wild-type controls

abnormal circulating insulin level ( J:234039 )

• following rosiglitazone treatment, HFD-fed mice show a significantly smaller reduction in fasting blood insulin levels relative to wild-type controls (55% versus 75%, respectively)

increased circulating insulin level ( J:234039 )

• after 12 weeks of HFD, mice exhibit significantly elevated re-fed blood insulin levels relative to wild-type controls

insulin resistance ( J:234039 )

• after 12 weeks of HFD, mice develop insulin resistance as measured by IPGTT and ITT

cellular

decreased adipocyte glucose uptake ( J:234039 )

• primary adipocytes derived from mutant inguinal white adipose tissue (iWAT), epididymal WAT, and brown adipose tissue (BAT) show a significantly reduced glucose uptake in response to an insulin stimulus relative to wild-type controls

• following rosiglitazone treatment, primary white and brown adipocytes from mutant mice fail to exhibit improved insulin-mediated glucose uptake, unlike similarly treated wild-type adipocytes