Phenotypes associated with this allele

• Allele Symbol: Tg(Lck-Stk17b)26.1Wals
• Allele Name: transgene insertion 26.1, Craig Michael Walsh
• Allele ID: MGI:4943694
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Lck-Stk17b)26.1Wals/? Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/6 * C57BL/10	MGI:5140299
tg2	Tg(Lck-Stk17b)26.1Wals/?	B6.Cg-Tg(Lck-Stk17b)26.1Wals	MGI:5140211

Genotype
MGI:5140299

cx1

• Allelic Composition: Tg(Lck-Stk17b)26.1Wals/?; Tg(TcraH-Y,TcrbH-Y)71Vbo/?
• Genetic Background: involves: C57BL/6 * C57BL/10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased thymocyte number ( J:149973 )

abnormal T cell differentiation ( J:149973 )

decreased CD8-positive, alpha-beta T cell number ( J:149973 )

• increased proportion of CD8+ thymocytes bearing H-Y clonotypic TCR

increased CD8-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD8+ T cells observed in females reflecting impaired positive selection

immune system

decreased thymocyte number ( J:149973 )

abnormal T cell differentiation ( J:149973 )

decreased CD8-positive, alpha-beta T cell number ( J:149973 )

• increased proportion of CD8+ thymocytes bearing H-Y clonotypic TCR

increased CD8-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD8+ T cells observed in females reflecting impaired positive selection

endocrine/exocrine glands

decreased thymocyte number ( J:149973 )

Genotype
MGI:5140211

tg2

• Allelic Composition: Tg(Lck-Stk17b)26.1Wals/?
• Genetic Background: B6.Cg-Tg(Lck-Stk17b)26.1Wals

hematopoietic system

increased T cell proliferation ( J:149973 )

• hyperproliferation in response suboptimal concentrations of anti-CD3

decreased thymocyte number ( J:149973 )

• numbers of total thymocytes are slightly reduced

enlarged spleen ( J:149973 )

• splenomegaly observed in some mice at 4-6 weeks of age and in all mice with age

increased spleen weight ( J:149973 )

spleen hyperplasia ( J:149973 )

• total number of splenic T cells is slightly increased

• hyperplasia of red and white pulp is observed

increased double-positive T cell number ( J:149973 )

• found in thymus

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:149973 )

decreased CD4-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD8+ T cells

decreased single-positive T cell number ( J:149973 )

immune system

increased T cell proliferation ( J:149973 )

• hyperproliferation in response suboptimal concentrations of anti-CD3

decreased thymocyte number ( J:149973 )

• numbers of total thymocytes are slightly reduced

enlarged spleen ( J:149973 )

• splenomegaly observed in some mice at 4-6 weeks of age and in all mice with age

increased spleen weight ( J:149973 )

spleen hyperplasia ( J:149973 )

• total number of splenic T cells is slightly increased

• hyperplasia of red and white pulp is observed

increased double-positive T cell number ( J:149973 )

• found in thymus

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:149973 )

decreased CD4-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD8+ T cells

decreased single-positive T cell number ( J:149973 )

increased interleukin-2 secretion ( J:149973 )

• IL2 levels are increased in response to suboptimal stimulation using anti-CD3

increased susceptibility to experimental autoimmune encephalomyelitis ( J:149973 )

• mice exhibit an earlier onset time and increased clinical severity as compared to controls

increased anti-nuclear antigen antibody level ( J:149973 )

• slightly elevated levels of ANA antibodies

endocrine/exocrine glands

decreased thymocyte number ( J:149973 )

• numbers of total thymocytes are slightly reduced

growth/size/body

enlarged spleen ( J:149973 )

• splenomegaly observed in some mice at 4-6 weeks of age and in all mice with age

increased spleen weight ( J:149973 )

spleen hyperplasia ( J:149973 )

• total number of splenic T cells is slightly increased

• hyperplasia of red and white pulp is observed

cellular

increased T cell proliferation ( J:149973 )

• hyperproliferation in response suboptimal concentrations of anti-CD3