Analysis Tools
mortality/aging
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• following administration of 60 or 120 ug cholera toxin
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immune system
| N |
• mice exhibit normal immunoglobulin concentrations in serum and feces
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• germinal center B cells from naive and immunized mice exhibit reduced somatic hypermutation compared with cells form wild-type mice
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• in Peyer's patches and spleen
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• mice immunized with sheep red blood cells (SRBC) exhibit a reduction in anti-SRBC IgG1 compared with similarly treated wild-type mice
• splenocytes stimulated with LPS and IL4 produce less IgG1 compared with similarly treated wild-type cells
• however, total IgG1 levels are normal
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• mice exposed to Y. enterocolitica exhibit increased numbers in mesenteric lymph nodes compared with similarly treated wild-type mice
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• following administration of 60 or 120 ug cholera toxin
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digestive/alimentary system
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• mice exhibit an increase in bacteria, especially anaerobic bacteria, in the small intestine compared with wild-type mice
• some mice exhibit an expansion of unclassified Lachnospiraceae of the order Clostridiales while others exhibit increased Bacteroidales or Lactobaccillus compared with wild-type mice
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hematopoietic system
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• germinal center B cells from naive and immunized mice exhibit reduced somatic hypermutation compared with cells form wild-type mice
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• in Peyer's patches and spleen
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• mice immunized with sheep red blood cells (SRBC) exhibit a reduction in anti-SRBC IgG1 compared with similarly treated wild-type mice
• splenocytes stimulated with LPS and IL4 produce less IgG1 compared with similarly treated wild-type cells
• however, total IgG1 levels are normal
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