Analysis Tools
cellular
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• chaperone-mediated autophagy is impaired in primary neuronal cultures as determined by the use of a photoactivatable fluorescent reporter to visualize movement from cytosol to lysosome
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nervous system
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• exogenous and endogenous alpha-synuclein is found associated to lysosomes and organized into irreversible oligomeric complexes in primary neuronal cultures
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homeostasis/metabolism
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• chaperone-mediated autophagy is impaired in primary neuronal cultures as determined by the use of a photoactivatable fluorescent reporter to visualize movement from cytosol to lysosome
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